与T2DM相关的口腔微生物群研究的进展:系统性审查
Mingming Huang1, Xinbi Zhang1, Leiming Di1
1Capital University of Physical Education and Sports, Beijing, China.
Frontiers in cellular and infection microbiology
|October 17, 2025
概括
口腔微生物群与2型糖尿病 (T2DM) 有着显著的联系. 监测口腔健康可能有助于T2DM的预防和管理.
科学领域:
- 微生物学 微生物学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 口腔微生物群在维持局部和全身健康方面发挥着至关重要的作用.
- 口腔微生物组的变化与各种系统性疾病有关.
- 了解口腔微生物群与2型糖尿病 (T2DM) 的联系对于全面的患者护理至关重要.
研究的目的:
- 系统地审查有关口腔微生物群组成与T2DM发展和进展之间的关联的现有文献.
- 识别与T2DM相关的口腔中的特定细菌种群.
- 评估口腔失生症在T2DM发病过程中的潜在作用.
主要方法:
- 按照PRISMA指南进行了系统审查.
- 从2000年4月到2025年4月,在PubMed/Medline,Web of Science和Scopus进行了文学搜索.
- 包括34项研究 (23项横截面,11项病例对照),涉及2062名T2DM患者和1445名对照.
主要成果:
- 在T2DM患者中,固体菌总是升高,而蛋白质细菌通常降低.
- 在T2DM种群中,菌株菌株,Porphyromonas和Treponema经常被丰富,在22项研究中,菌株菌株菌株升高.
- 鉴定出 Porphyromonas gingivalis 是一种可能导致 T2DM 系统性炎症和胰岛素抵抗的潜在因素.
结论:
- 口腔微生物群组成和T2DM之间存在显著的关联.
- 口腔失生症,以特定的细菌转移为特征,与T2DM病原发生有关.
- 口腔健康监测对于T2DM预防和管理策略可能很重要.
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