评估体外维生素D补充剂及其对精子质量的影响:一项受控实验研究
Chaimaa Hilali1,2,3, Ez-Zahidy Douae2, Chafika Nadifi1,2,3
1Mohammed VI University of Health and Sciences (UM6SS), Oncopathology Cancer Biology and Environment Laboratory, Mohammed VI Faculty of Medicine, Casablanca, Morocco.
Journal of human reproductive sciences
|October 17, 2025
概括
维生素D补充改善了体外精子的运动性和DNA完整性. 这表明维生素D可能会增强男性生育能力,这需要进一步的临床研究.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 精子的功能 精子的功能
背景情况:
- 维生素D被认为有助于骨健康和免疫功能.
- 新兴研究将维生素D与男性生殖健康和精子质量联系起来.
- 适当的维生素D水平可能会改善男性生育能力的结果.
研究的目的:
- 研究各种维生素D度对精子关键参数的体外影响.
- 评估维生素D对精子运动性,活力,DNA碎片化和脱凝的影响.
主要方法:
- 一项前性体外研究,涉及100个精液样本 (50个常态种类,50个类种类).
- 精子样本与不同度的维生素D (1.625 × 10−1 M至1.625 × 10−4 M) 进行化,持续5分钟,15分钟或30分钟.
- 标准化试验用于评估精子运动性,活力,DNA碎片化指数 (DFI) 和DNA脱凝.
主要成果:
- 在两个样本类型中,在1.625 × 10−3 M维生素D下观察到精子运动的显著改善.
- 在测试度之间,精子活力没有显著变化.
- 在DFI和DNA脱凝指数 (P < 0.001) 中发现了统计学上显著的改善.
结论:
- 在体外维生素D补充剂对精子运动性和DNA完整性产生积极影响.
- 维生素D显示出作为增强男性生育能力的治疗方法的潜力.
- 需要进一步的大规模研究来证实发现并建立临床指南.
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