肝细胞癌的新辅助全身疗法:挑战和机遇 - - 叙述性综述
Yunpu Zhang1,2,3, Shiwei Yue1,2,3, Bixiang Zhang1,2,3
1Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hepatobiliary surgery and nutrition
|October 17, 2025
概括
新辅助性全身疗法,特别是免疫疗法,在减少接受手术的肝细胞癌 (HCC) 患者复发方面表现有前途. 需要进一步的研究来优化其使用以改善长期生存.
科学领域:
- 肝胆道手术是肝胆道的手术.
- 医学瘤学 医学瘤学
- 翻译性癌症研究
背景情况:
- 肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
- 目前治疗早期HCC的治疗方法包括切除,肝移植和切除.
- 高的术后复发率显著影响患者的预后.
研究的目的:
- 审查可切除的HCC新辅助全身治疗的安全性和有效性.
- 探索新辅助性HCC管理中系统治疗的未来方向.
- 总结关于治疗意图肝切除或移植后改善结果的证据.
主要方法:
- 使用关键词对PubMed的系统文献搜索:肝细胞癌,新辅助,术前,化疗,向治疗,全身治疗,免疫治疗.
- 包括在ClinicalTrials.gov.gov注册的相关正在进行的临床试验.
- 对可切除HCC的新辅助系统治疗现有证据的审查.
主要成果:
- 系统疗法 (抗VEGF,TKI,免疫疗法) 的进步改善了晚期HCC的存活率.
- 这些进展正在推动对HCC的新辅助和辅助系统治疗的探索.
- 有证据表明,新辅助性全身疗法可以减少瘤负担,并可能消除微转移.
结论:
- 新辅助免疫疗法,特别是免疫检查点抑制剂,在预防HCC复发和改善生存率方面显示出有前途.
- 组合疗法 (使用抗血管原药的免疫疗法,局部区域疗法) 似乎最有效.
- 进一步的研究对于确定最佳候选者,生物标志物,治疗方案和手术时间至关重要.
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