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短波红外空间频域成像用于检测组织水分的变化

Thomas T Livecchi¹, Steven L Jacques², Anahita Pilvar³

¹Biomedical Engineering Department, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.

Frontiers in photonics

|October 17, 2025

概括

使用短波红外 (SWIR) 光的空间频域成像 (SFDI) 有效地测量了组织水分. 由SWIR-SFDI检测到的减少的散射变化表明水含量变化,显示出临床诊断的潜力.

科学领域:

生物医学光学生物医学光学
医疗成像医学成像
生理监测生理监测

背景情况:

组织中的水和脂质含量是健康和疾病的关键生物标志物.
空间频域成像 (SFDI) 提供了组织部件的非侵入性量化.
短波红外线 (SWIR) 光可以进行新的光学属性测量.

研究的目的:

引入和验证基于LED的SWIR SFDI系统,用于测量组织水分.
为了评估光学特性对水含量变化的敏感性.
探索SWIR SFDI在非侵入性水分评估中的临床潜力.

主要方法:

验证了使用受控水脂稀释的SWIR SFDI系统.
在干燥过程中将SWIR-SFDI应用于ex vivo猪皮肤.
在运动前和运动后对人类受试者的手进行体内成像.

主要成果:

该系统准确地量化了稀释中的染色体.
减少散射系数的变化对干燥皮肤的水分损失敏感.
在体内运动诱导的减少减少散射,与水分流失相关.

结论:

减少的散射系数是组织水化变化的敏感指标.
斯威尔SFDI显示了对非侵入性水分监测的潜力.
这种技术在临床诊断和生理评估方面表现有前途.

关键词:

原蛋白是一种原蛋白.运动就是炼身体.多光谱的多光谱.流汗汗水流汗流汗散射散射是一种散射.短波红外线是短波的红外线.组织水化组织水化

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