相关实验视频

Updated: May 9, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

亚洲可以改善老年小鼠的睡眠质量和数量

Laura Dovek¹, Carolyn E Tinsley^1,2, Katelyn Gutowsky³

¹Department of Neurology, Oregon Health and Science University, Portland, OR, United States.

Sleep advances : a journal of the Sleep Research Society

|October 17, 2025

概括

亚洲水提取物 (CAW) 在老年小鼠的睡眠改善方面显示出有前途. 这项研究发现,CAW在老年小鼠中适度改善了睡眠量和质量,并观察到取决于性别的效应.

科学领域:

神经科学是一个神经科学.
老年学是指老年学的学科.
药理学药理学是指药理学的学科.

背景情况:

与年龄相关的睡眠障碍很常见,影响认知功能,增加痴呆风险.
睡眠下降可能导致与年龄相关的认知衰退和神经退行性疾病.
亚洲的提取物表现出神经保护作用,但它们对睡眠的影响尚不清楚.

研究的目的:

为了研究Centella asiatica水提取物 (CAW) 对老年小鼠睡眠模式的影响.
为了确定CAW是否可以减轻与年龄相关的睡眠衰退.
探索CAW对睡眠的潜在性取决影响.

主要方法:

年龄较大的雄性和雌性C57BL6/J小鼠 (18个月大) 被食含CAW (1000 mg/kg/天) 或对照食.
使用电脑电图 (EEG) 和电脑电图 (EMG) 记录来分析睡眠组成.
评估了对睡眠持续时间,REM睡眠,Theta功率和唤醒的影响.

主要成果:

在老年雄性小鼠中,CAW增加了REM睡眠的持续时间和REM睡眠期间的太功率.
在老年雌性小鼠中,CAW降低了睡眠唤醒的次数.
与年龄和性别匹配的对照组相比,观察到这些效应.

结论:

Centella asiatica水提取物 (CAW) 对老年小鼠的睡眠量和质量具有适度的,取决于性别的影响.
对于与年龄有关的睡眠障碍,CAW可能是一种潜在的干预措施.
需要进一步的研究来阐明CAW对睡眠和认知的机制和长期影响.

关键词:

在NREM和REM循环中.快速眼睛运动 (REM) 睡眠是什么?老化的老化衰老的老化动物模型动物模型睡眠与大脑的关系

更多相关视频

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Establishing a Device for Sleep Deprivation in Mice

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

相关概念视频

Management of Insomnia

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...

Insufficient Sleep and Sleep Deprivation

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...