可注射水凝用于可编程纳米粒子释放
Wenting Shi1, Ying Xi1, Xinyi Sheng1
1School of Chemistry and Biochemistry, Georgia Institute of Technology Atlanta, GA 30332, USA.
Advanced functional materials
|October 17, 2025
概括
这项研究介绍了一种新的可注射水凝系统,用于持续释放生物分子. 基于德克斯和聚乙烯甘醇的材料允许在两周内控制药物输送,减少注射频率.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 可注射的水凝为生物分子的持续释放提供了一个有希望的方法,最大限度地减少了频繁注射的需要.
- 开发具有可控凝和降解动力学的水凝系统对于有效的体内应用至关重要.
研究的目的:
- 开发一种新的可注射水凝系统,用于可编程,持续释放病毒样颗粒 (VLP).
- 在两周的时间内设计可调节的释放配置文件 (爆发,线性,延迟).
- 为生物医学应用中可降解材料创建一个可通用的平台.
主要方法:
- 德克斯和聚乙烯甘醇 (PEG) 聚合物的合成,分别与氧化诺波纳 (OND) 和硫醇组功能化.
- 使用迈克尔添加剂通过注射器到注射器混合来控制水凝的形成.
- 在VLP释放中采用反复-Diels-Alder和水解性体键裂解.
- 用于评估皮下注射的水凝硬度的风病学表征.
主要成果:
- 开发的水凝系统证明了有效的VLP货物的捕获 (>95%).
- 通过修改OND链接,实现了可编程的释放配置文件,包括两个星期的爆发,线性和延迟释放.
- 风湿学特性证实水凝具有适合皮下注射的刚性.
结论:
- 这种新型可注射水凝系统为生物分子的持续释放提供了一个多功能平台.
- 该系统允许精确控制药物释放动力学,从而有可能减少注射频率.
- 这种模块化方法可用于开发各种生物医学应用的先进可降解材料.
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