一个社区的军团病爆发与集体生物质冷凝炉有关,法国,2019年
Sophie Raguet1, Christophe Ginevra2,3,4,5, Ghislaine Descours2,3,4
1The French Public Health Agency, Grand Est, Strasbourg, France.
概括
斯特拉斯堡的一次军团病爆发被追溯到一个生物质炉. 基因组分析证实了来源,强调了新型节能加热系统带来的风险.
科学领域:
- 环境微生物学环境微生物学
- 流行病学 流行病学
- 基因组流行病学基因组流行病学
背景情况:
- 军团病 (LD) 爆发带来公共卫生风险.
- 识别LD爆发的来源对于控制至关重要.
研究的目的:
- 调查斯特拉斯堡LD疫情的来源和传播.
- 通过基因组方法来表征因果性军团菌株.
- 评估生物质加热系统在LD传输中的作用.
主要方法:
- 流行病学调查,包括病例发现和空间绘制.
- 环境采样和培养Legionella菌.
- 临床和环境分离的基于序列的类型化和全基因组测序 (WGS).
主要成果:
- 诊断出28例LD病例,其中包括2例死亡.
- 这次爆发与L. pneumophila血清组1 (Lp1) 序列类型 (ST) 62.2有关.
- 在一个被确定为疫情中心的供暖厂的生物质冷凝炉中发现了高水平的LP 1 ST62.
- 据WGS证实,临床和环境分离物之间存在密切的遗传关系.
结论:
- 生物质炉是LD爆发的来源.
- 低于最佳的维护和温暖的天气可能导致了细菌的增殖.
- 创新的节能加热工艺可能会给LD传输带来新的风险.
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