赫斯佩里丁减轻了大鼠中的烯胺诱导的卵巢毒性:基于网络药理学,分子对接和体内研究
Divya Gupta1, Sadhana Shrivastava1, Chakresh Kumar Jain2
1Reproductive Biology and Toxicology Lab, School of Studies in Zoology, Jiwaji University, Gwalior, India.
Environmental toxicology
|October 17, 2025
概括
黑斯佩里丁 (HES) 保护大鼠免受烯胺 (AA) 诱导的卵巢毒性. 这种植物性化合物具有显著的抗氧化特性,为抗食物毒素提供了潜在的治疗策略.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 从食物中接触到烯胺 (AA) 是普遍存在的,并且与生殖毒性有关,包括卵巢重量和卵泡数量的减少.
- 黄类化合物,像hesperidin (HES),是植物衍生的生物活性化合物,具有潜在的药物应用.
研究的目的:
- 在大鼠模型中研究素 (HES) 对烯胺 (AA) 诱导的卵巢损伤的保护作用.
- 通过生物信息学分析,识别涉及HES治疗和AA毒性的潜在目标基因和途径.
- 通过分子对接来评估AA,HES和核心目标基因之间的分子相互作用.
主要方法:
- 鼠被口服烯胺 (40毫克/公斤) 持续10天,然后在3天内服用不同剂量的烯胺.
- 评估包括生殖激素水平,氧化应激标志物,膜结合酶,糖原含量和组织学检查.
- 生物信息分析,包括功能丰富和途径分析,对已识别的目标基因进行. 分子对接被用来研究基因-连接体相互作用.
主要成果:
- 素 (HES) 在体内表现出显著的保护作用,防止烯胺 (AA) 诱导的卵巢损伤.
- HES显示出强烈的抗氧化特性,减轻氧化应激标志物,并保持卵巢功能.
- 分子对接揭示了HES和核心标蛋白之间的高结合亲和力,这表明了直接的作用机制.
结论:
- 赫斯佩里丁具有显著的保护能力,可以抵抗烯胺诱导的老鼠生殖毒性.
- HES的抗氧化活性是其保护机制的关键因素,防止AA诱导的卵巢损伤.
- 高胺是一种有前途的治疗剂,可以减轻饮食中的烯胺暴露的不良影响.
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