免疫受损人群中的深度和扩散性皮肤植物病- 一个系统性审查
Aditya K Gupta1,2, Tong Wang2, Susmita2
1Division of Dermatology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
概括
深层皮肤植物病是一种罕见的真菌感染,在免疫功能低下的个体中可以变得侵入性. 早期诊断和治疗对于管理这些严重感染至关重要.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 免疫受损宿主研究
背景情况:
- 皮质菌是全球常见的真菌病原体,影响皮肤,头发和指甲.
- 深层皮肤植物病是一种罕见但严重的并发症,特别是在免疫受损的个体中.
- 侵入性感染可能导致全身传播和伪肌瘤.
研究的目的:
- 审查患者的特征,风险因素,诊断和治疗深层皮肤植物病.
- 了解侵入性真菌感染的流行病学和临床表现.
- 为了告知临床实践关于皮肤菌感染在弱势群体.
主要方法:
- 1954年至2025年间发表的研究的系统审查.
- 包括无毛皮肤的深层皮肤植物病例.
- 排除马约基粒瘤;通过组织病理学和真菌培养进行验证.
主要成果:
- 在96项研究中记录了134名患者,自2000年以来报告增加.
- 最常见的病原体是Trichophyton rubrum;免疫缺陷 (获得/初级) 是一个关键的危险因素.
- 系统传播发生在24名患者中;特比纳和伊特拉科纳是常见的治疗方法,多重耐药性是令人担忧的.
结论:
- 皮肤植物病可以在免疫功能低下的患者中变得侵入性和传播性.
- 医疗保健提供者必须认识到这种潜在的入侵性疾病.
- 及时检测和早期干预对于管理深层皮肤植物病至关重要.
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