在2019-2023年对95种差异化甲状腺癌/形甲状腺癌的个性化治疗
Nai-Si Huang1,2, Jia-Ying Chen1,2, Wen-Jun Wei1,2
1Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
European thyroid journal
|October 17, 2025
概括
积极的治疗,包括新辅助疗法,显著改善了差差分化甲状腺癌 (PDTC) 和形甲状腺癌 (ATC) 患者的生存率. 个性化治疗策略对于在这些罕见和积极的甲状腺癌中获得更好的结果至关重要.
科学领域:
- 在瘤学瘤学.
- 甲状腺癌研究研究
- 癌症治疗方法 癌症治疗方法
背景情况:
- 差分化甲状腺癌 (PDTC) 和形甲状腺癌 (ATC) 是罕见的,激进的甲状腺癌形式.
- 针对性治疗和免疫治疗的最新进展为患者提供了新的治疗途径和改善的预后.
- 了解治疗疗效和遗传改变对于管理这些具有挑战性的恶性瘤至关重要.
研究的目的:
- 分析局部晚期或转移PDTC/ATC的患者的治疗策略和结果.
- 为了确定PDTC和ATC中常见的基因变异.
- 评估不同治疗方式对整体存活时间的影响.
主要方法:
- 在2019-2023年期间诊断出PDTC/ATC的95名患者的单中心队列研究.
- 患者通过临床试验,指南或专家共识接受治疗.
- 下一代测序用于临床样本的基因测试.
主要成果:
- 总生存 (OS) 的中位数为PDTC的19.7个月,ATC的9.5个月.
- 常见的基因变异包括TERT促进体,BRAF和TP53突变在PDTC和ATC.
- 手术后的新辅助疗法是优越的OS的独立预测因子 (HR=0.216,P=0.012).
结论:
- 积极的治疗,特别是与手术相结合的新辅助疗法,显著改善了PDTC/ATC患者的生存率.
- 个性化治疗方法对于优化治疗策略至关重要.
- 针对这些侵袭性甲状腺癌,需要对向疗法和免疫疗法进行进一步的研究.
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