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Beth K Neilsen1, Rong Rong Huang2, Luca F Valle1

  • 1Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, California.

International journal of radiation oncology, biology, physics
|October 17, 2025
PubMed
概括

与新发性癌症相比,局部放射性复发性前列腺癌 (LRR-PCa) 显示出不同的基因组和转录组概况. LRR-PCa在攻击性和DNA修复基因中表现出增加的突变,更高的解密得分和基本亚型.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...