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相关概念视频

Steady Flow of a Fluid Stream01:27

Steady Flow of a Fluid Stream

Consider a control volume, such as a pipe with solid boundaries, through which fluid flows and changes direction due to the impulse exerted by the resulting force from the pipe walls. In steady flow, the mass of fluid entering the control volume at a given time, t, with velocity v1, is equal to the mass leaving after infinitesimal time dt, with velocity v2.
During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...
Control Volume and System Representations01:16

Control Volume and System Representations

Two key frameworks are employed to analyze mass, energy, and momentum transfer: the control volume approach and the system approach. These frameworks offer different perspectives, depending on whether the focus is on a specific region in space (control volume approach) or a defined mass of fluid (system approach).
The control volume approach considers a stationary region in space through which fluid flows. This region is bounded by a control surface.  For instance, in the case of water flowing...
Conservation of Mass in Finite Cotrol Volume01:16

Conservation of Mass in Finite Cotrol Volume

The principle of conservation of mass is a fundamental law in fluid mechanics and is applied using the continuity equation. We apply the concept to a finite control volume to derive the continuity equation.
A system is defined as a collection of unchanging contents, and the conservation of mass states that a system's mass is constant.
Conservation of Mass in Fixed, Nondeforming Control Volume01:07

Conservation of Mass in Fixed, Nondeforming Control Volume

The principle of conservation of mass is fundamental in fluid dynamics and is crucial for analyzing flow within fixed control volumes, such as pipes or ducts. This principle states that the total mass within a control volume remains constant unless altered by the inflow or outflow of mass through the control surfaces. This results in a vital relationship for steady, incompressible flow where the mass entering a system equals the mass leaving it.
In the case of a sewer pipe, which can be modeled...
Laminar Flow01:27

Laminar Flow

Laminar flow represents a smooth, orderly fluid motion where particles move along parallel paths, resulting in minimal mixing between layers. Streamlined particle paths characterize this flow regime and occur under conditions where viscous forces dominate over inertial forces. The distinction between laminar, transitional, and turbulent flow is primarily determined by the Reynolds number, a dimensionless quantity calculated as:
Laminar Flow: Problem Solving01:24

Laminar Flow: Problem Solving

Laminar flow occurs when a fluid moves smoothly in parallel layers with minimal mixing and turbulence. In fluid mechanics, ensuring laminar flow within a pipe is essential for precise control of flow characteristics, especially in engineering applications. The key factor in determining whether flow remains laminar is the Reynolds number, a dimensionless quantity that depends on the fluid's velocity, density, viscosity, and the pipe's diameter. A Reynolds number of 2100 or lower indicates...

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微流体流量聚焦用于控制尺寸的立方体形成.

Celso J O Ferreira1,2,3,4, Margarida Barros1,2, Marco Fornasier4

  • 1INL-International Iberian Nanotechnology Laboratory, Braga 4715-330, Portugal.

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概括
此摘要是机器生成的。

一种新的微流体方法通过调整溶剂交换期间的流速来精确控制药物输送的立方体大小. 这种技术提供了可调节的颗粒大小,优于传统的散装方法.

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科学领域:

  • 材料科学 材料科学 材料科学
  • 纳米技术 纳米技术
  • 制药科学 制药科学

背景情况:

  • 立方体是先进的基于脂质的纳米系统,用于药物输送.
  • 控制立方体大小对于优化药物递送效率至关重要.
  • 传统的散装溶剂交换方法缺乏精确的尺寸控制.

研究的目的:

  • 开发一种微流体液态动力学流量聚焦方法,用于立方体准备.
  • 通过溶剂交换来实现对立方体粒子大小的调节控制.
  • 研究流速比对立方体自我组装动力学和大小的影响.

主要方法:

  • 使用一个十字形的微流体装置用于水力动力流动聚焦.
  • 在乙醇中制备的植物醇脂的前体溶液.
  • 聚焦的前体溶液与含有Pluronic F127稳定剂的横向水流,用于控制溶剂交换和自组装.

主要成果:

  • 成功调整了从195nm到125nm的立方体体大小.
  • 通过增加流速比率 (QR) 证明了粒子大小的单调减少.
  • 实现了低至中等的多分散指数,具有统计学上显著的趋势 (p ≤0.011).

结论:

  • 微流体液态动力流聚焦提供了对立方体体大小的精确控制.
  • 这种方法在可调节纳米粒子制备的散装溶剂交换上提供了显著的优势.
  • 进一步的设备优化可以提高复制性和可扩展性,用于先进的药物输送应用.