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睡眠期间的定期四肢运动,不安腿综合征和老年人的认知变化:基于人口的纵向研究
Nicola Andrea Marchi1, Geoffroy Solelhac1, Théo Imler1
1Center for Investigation and Research in Sleep, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Sleep
|October 17, 2025
概括
睡眠期间高周期性四肢运动 (PLMS) 与老年人执行功能下降的速度更快有关. 不安腿综合征 (RLS) 症状没有显示这种关联.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 认知科学 认知科学
背景情况:
- 在老年人中,睡眠期间定期肢体运动 (PLMS) 和不安腿综合征 (RLS) 是常见的.
- 它们对纵向认知变化的影响尚不清楚.
研究的目的:
- 调查PLMS和RLS症状与老年人的认知表现随时间变化的关联.
- 确定高PLMS频率或RLS症状是否预测认知能力下降.
主要方法:
- 对382名老年人 (平均年龄71岁) 5年多的多睡眠和认知数据的分析.
- 参与者按PLMS指数 (PLMI) 分类;对执行功能,口语流和记忆进行认知变化评估.
- 多重线性回归模型对混因素进行了调整;RLS症状和相互作用也得到了评估.
主要成果:
- 高的PLMI (≥30/h) 与加速的执行功能下降显著相关 (B=-0.06 SD/年,p=0.010).
- 这种关联独立于RLS症状和其他睡眠状况.
- 没有发现PLMI或RLS症状与口语流性或记忆力变化之间的显著关联.
结论:
- 高频率的PLMS独立地与老年人更快的执行功能恶化有关.
- 这表明PLMS在认知衰老中的潜在作用.
- 在这个队列中,RLS症状与认知变化无关.
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