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线粒体UPR是复星中介抗菌免疫所需的
Yan Zhang1,2,3, Xiaocong Li4, Rui Zhao1,2,3
1The Key Lab of Guizhou Provincial Department of Education for Medical Prevention and Treatment of Tumor, Zunyi Medical University, Zunyi Guizhou 563000, China. xiaoyizmu@126.com.
Food & function
|October 17, 2025
概括
ресвератрол通过激活线粒体展开蛋白质响应 (UPR) 途径来增强先天免疫力,增强对像 Pseudomonas aeruginosa 这样的细菌感染的抵抗力. 这种天然化合物提供了一种对抗抗生素耐药性的有希望的策略.
科学领域:
- 免疫学和微生物学
- 线粒体生物学 线粒体生物学
- 自然产品治疗药物 自然产品治疗药物
背景情况:
- 线粒体展开蛋白质反应 (UPRmt) 对于线粒体平衡至关重要,并影响先天免疫力.
- 葡萄和花生中的多醇resveratrol已知具有抗炎和抗氧化特性,但其在天生的免疫力中的作用尚不清楚.
- 了解天然化合物如何调节免疫力对于开发新的抗感染策略至关重要.
研究的目的:
- 为了研究复星是否能调节对*Pseudomonas aeruginosa*感染的先天免疫力.
- 阐明白醇免疫调节作用的潜在分子机制.
- 探索复星作为一种基于天然化合物的抗感染疗法的潜力.
主要方法:
- 在细胞和动物模型中对白醇对*P. aeruginosa*PA14感染耐药性的剂量依赖性评估.
- 对抗微生物 *irg-1* 表达和肠道细菌负荷的分析.
- 研究复星对ATFS-1-依赖的UPRmt通路和ATF5激活的影响.
- 在接受白醇治疗的小鼠中评估生存率,细菌负担和基因表达.
主要成果:
- ресвератрол显著增强了对 *P. aeruginosa* PA14 感染的耐药性,这种耐药性取决于剂量.
- 这种保护是通过对抗微生物 *irg-1* 的上调和降低细菌负载来调节的,而不是直接的抗微生物活性.
- Resveratrol激活了ATFS-1-依赖的UPRmt通路,增加了ATFS-1表达和下游的免疫保护基因.
- 在人类细胞和小鼠中,白醇通过ATF5激活了UPR,改善了生存率并减少了细菌负担.
结论:
- 复星通过激活ATFS-1/ATF5-UPRmt轴来增强对细菌感染的天生的免疫力.
- 这项研究揭示了resveratrol增强免疫力的新机制,突出了其在抗感染疗法中的潜力.
- 研究结果支持使用植物多用于免疫调节,并提供打击抗生素耐药性的策略.
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