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肺癌手术期间脏洗细胞学的连续变化预测了复发和脏扩散

Go Kamimura¹, Masaya Aoki², Satomi Imamura²

¹Department of General Thoracic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan. k6474547@kadai.jp.

|October 17, 2025

概括

在非小细胞肺癌 (NSCLC) 外科手术中的手术内淋浴细胞学 (PLC) 是预后性的. 切除后的PLC,而不是切除前的PLC,可以预测复发和膜传播,指导辅助治疗决策.

科学领域:

胸部外科手术胸部外科手术
在瘤学瘤学.
细胞病理学细胞病理学

背景情况:

胸腔洗细胞学 (PLC) 是非小细胞肺癌 (NSCLC) 的预后标志物.
连续性手术内PLC变化对患者结局的影响尚不清楚.

研究的目的:

在接受非小细胞肺癌 (NSCLC) 切除的患者中,研究连续的手术内腹腔洗细胞学 (PLC) 的预后意义.
为了确定切割前或切割后的PLC是否更能预测复发和膜扩散.

主要方法:

对439名患有治愈性NSCLC切除的患者的回顾性分析.
在三个手术时间点收集的PLC:洗前 (PLC前),切割后和洗后 (PLC后).
卡普兰-梅尔分析和Fine和Gray竞争风险回归用于评估无复发生存率 (RFS) 和多叶膜传播.

主要成果:

41名患者至少有一次阳性PLC结果.
后PLC阳性独立预测了较差的RFS (HR,3.06;p < 0.001),而前PLC阳性则没有.
负的PLC后患者,即使是正的PLC前患者,也有类似于始终负的病例的RFS.

结论:

切除后PLC是NSCLC中复发和膜扩散的决定性预后指标.
将PLC前后结果结合起来可以提高风险分层,识别潜在辅助治疗的高风险子组.

关键词:

腹洗细胞学腹洗细胞学胸部闭塞时的多淋浴细胞学.在胸腔切除术后立即进行多叶膜洗细胞学.

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