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双极性障碍药物与骨折非结合的可能性增加有关
Samuel S Gay1,2, Adam Nguyen3,4, Jared D Wainwright3,4
1The University of Texas Medical Branch at Galveston, Galveston, USA. ssgay@utmb.edu.
Archives of orthopaedic and trauma surgery
|October 17, 2025
概括
双极性障碍 (BD) 药物,而不是BD本身,增加了关闭骨折中的非结合几率. 开放的骨折没有受到影响. 外科医生应该为服用药物的BD患者调整治疗.
科学领域:
- 整形外科手术 整形外科手术
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 双极性障碍 (BD) 是一种影响骨健康的心理健康状况.
- 骨折非结合是整形外科手术中的一个重要并发症.
- BD及其治疗对骨折愈合的影响需要进一步调查.
研究的目的:
- 评估双相情感障碍 (BD) 患者骨折非结合的几率.
- 调查BD药物对非工会率的影响.
- 在BD患者中区分开放和封闭骨折的结果.
主要方法:
- 使用TrinetX研究数据库进行回顾性队列研究.
- 对年龄,性别,物质使用,并发症和药物史进行倾向得分匹配 (1:1).
- 对18岁以上患者长骨折的分析,将BD患者与对照进行比较.
主要成果:
- 患有BD的患者 (3.9%) 与没有BD的患者 (3.2%) 的非联合率更高.
- 开放式骨折显示BD和非BD组之间的非工会率没有显著差异.
- 在BD患者中,闭骨折的非结合几率较高 (OR 1.30),BD药物治疗显著增加 (OR 1.68).
结论:
- 药物治疗BD,而不是BD本身,与密闭骨折中非结合率的增加有关.
- 开放骨折没有受到BD或其药物的显著影响.
- 整形外科医生在治疗BD患者骨折时应考虑药物效应.
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