在随访期间,持续的乳病抗体阳性的患病率和预测因素
Brandon S Cohen1, Suzanne K Lewis2, Suneeta Krishnareddy2
1Department of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, NY, USA. bsc77@cornell.edu.
Digestive diseases and sciences
|October 17, 2025
概括
持续的乳性疾病抗体很常见,在诊断后的一年内影响超过25%的患者. 最近的诊断和种族等因素会影响持续的血清阳性,这可能表明持续的状缩.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 乳病的管理包括症状评估和坚持无质饮食.
- 血清标记器经常用于监测避免质,尽管依赖于饮食专家的采访.
- 确定与持续的血清阳性相关的因素对于患者的随访至关重要.
研究的目的:
- 确定与持续的乳性疾病血清阳性相关的人口和临床因素.
- 在诊断后至少一年内调查抗体升高的预测因子.
主要方法:
- 对于成年患有乳病的患者进行了回顾性队列研究.
- 对人口统计数据和血清学结果的分析 (tTG IgA,脱胺基质素IgA/IgG).
- 单变量和多变量分析以确定与持续的血清阳性相关的因素.
主要成果:
- 超过25%的患者 (156/541) 在诊断一年后表现出持续的血清阳性.
- 最近的诊断 (p<0.001) 和非白人/未知种族 (p=0.004) 与持久的积极性有关.
- 持续的阳性与较高的马什得分 (3a或更高) 相关联,表明潜在的正在进行的小缩.
结论:
- 持续升高的乳病抗体是常见的,与最近的诊断和种族有关.
- 诊断后的时间等临床因素可以帮助预测持续的血清阳性.
- 预测持续的血清阳性可能有助于识别患有持续状缩风险的患者.
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