聚烯微塑料 (PS-MPs) 在亚急性暴露后扰乱骨肌肉能量代谢和组织结构:一个剂量响应研究
Susmita Chakraborty1, Sudipta Pal2
1Nutritional Biochemistry and Toxicology Laboratory, Department of Human Physiology, Tripura University, Suryamaninagar, 799022, West Tripura, India.
Journal of muscle research and cell motility
|October 17, 2025
概括
聚烯微塑料 (PS-MP) 破坏了骨肌肉的能量代谢,并导致大鼠的退化. 暴露于PS-MP减少了食物摄入量,耗尽了糖原,并改变了关键的代谢酶,导致肌肉损伤.
科学领域:
- 环境毒理学环境毒理学
- 生物化学 生物化学
- 细胞生物学 细胞生物学
背景情况:
- 聚烯微塑料 (PS-MP) 是普遍存在的环境污染物.
- 之前的研究表明PS-MP对动物有不良影响.
研究的目的:
- 调查PS-MP对Wistar大鼠骨肌肉能量代谢的剂量依赖影响.
- 分析PS-MP暴露后的代谢概况和组织学变化.
主要方法:
- 维斯特大鼠在饮用水中口服了PS-MP,剂量各不相同 (0.5,5,50毫克/升),持续了28天.
- 进行了代谢分析,酶活性测定和肌肉组织组织学检查.
主要成果:
- 暴露在PS-MP下降了食物消耗,并以剂量依赖的方式降低了肌肉糖原和酸盐水平.
- 乳酸脱酶,转氨酶和TCA循环酶的活性降低,表明代谢功能障碍和组织损伤.
- 组织学分析显示肌肉缩,核迁移和纤维化,表明显著的退行性变化.
结论:
- 暴露于PS-MP会扰乱骨肌肉的能量代谢,导致葡萄糖利用和能量产生受损.
- 低急性暴露于PS-MP促进肌肉纤维退化,并改变关键的代谢途径.
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