3个月的嗅觉训练在COVID-19后的帕洛斯米亚的现实世界结果
Xinni Xu1,2, Kristóf Peter Ludányi3, Jerry Hadi Juratli4
1Smell and Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, Dresden, Germany, xinni_xu@nuhs.edu.sg.
ORL; journal for oto-rhino-laryngology and its related specialties
|October 17, 2025
概括
嗅觉训练 (OT) 在3个月后在52.6%的患者中改善了COVID-19相关的鼻和嗅觉功能. 高度遵守OT与更好的帕洛斯米亚改善相关,尽管单独改善嗅觉功能并不能保证帕洛斯米亚的缓解.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19 parosmia是一个重大挑战,影响生活质量.
- 嗅觉训练 (OT) 对帕洛斯米亚的有效性仍然不完全理解.
- 这项研究解决了需要证据的OT在管理持续的COVID-19相关 parosmia的有效性.
研究的目的:
- 评估一个为期3个月的嗅觉训练方案对COVID-19相关的影响.
- 为了确定定量嗅觉功能的改善和患者遵守OT是否会影响帕洛斯米亚恢复.
- 为了评估干预后帕洛斯米亚强度,愉快度和享乐范围的变化.
主要方法:
- 一项前性队列研究,涉及38名患有COVID-19后持续性帕罗斯米亚的患者.
- 患者接受了为期3个月的每天两次的嗅觉训练 (OT).
- 在训练前和训练后,使用经过验证的天平和Sniffin' Sticks测试,评估了帕洛斯米亚和嗅觉功能 (TDI分数).
主要成果:
- 超过52%的参与者在经过3个月的OT后报告了对帕洛斯米亚的主观改善.
- 在感知愉悦度,享乐范围和TDI得分方面观察到显著改善.
- 较高的OT遵守率 (>70%) 与享乐范围 (p=0.04) 的更大改善有关.
结论:
- 嗅觉训练 (OT) 显示出在改善COVID-19后的帕洛斯米亚和一般嗅觉功能障碍方面的潜力.
- 虽然嗅觉功能可能会得到改善,但这并不总是意味着更好地感知parosmia.
- 患者对OT的坚持和遵守是影响帕洛斯米亚改善程度的关键因素.
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