法国年轻牛和猪生产中胆固醇耐药性的降低:与胆固醇使用和管理措施的关系
Claire Chauvin1, Eric Jouy2, Anne Chevance3
1ANSES Ploufragan Plouzané Niort Laboratory, Epidemiology Health and Welfare (EPISABE) Unit, Ploufragan, France.
The Journal of antimicrobial chemotherapy
|October 17, 2025
概括
法国的管理措施显著减少了猪和牛的胆固醇使用和耐药性. 长期数据显示,这些政策有效地保护了胆固醇.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 抗微生物药物管理管理
- 食品动物生产动物生产
背景情况:
- 胆固醇是人类感染的关键最后一线抗生素.
- 畜牧业中抗菌素耐药性的增加需要政策评估.
- 对素使用政策的长期影响评估至关重要.
研究的目的:
- 确定法国猪和牛养殖中的科里斯管理措施.
- 分析这些措施对素使用和耐药性的长期影响.
主要方法:
- 监管机构和利益相关方对监管措施的清单.
- 收集的抗微生物药物使用数据 (销售,农场) 和耐药性监测数据.
- 分析了动物素暴露和大肠杆菌耐药性的时间序列数据 (2008-2023年).
主要成果:
- 在法国逐步实施各种管辖措施.
- 牛和猪生产中的胆固醇暴露显著下降,达到平原.
- 同时显著降低胆固醇抗性,具有显著的时间序列关联.
结论:
- 法国的长期数据证明了管辖措施的有效性.
- 在食品动物中,胆固醇的使用和耐药性显著下降.
- 这些政策保护了科里斯对动物和人类健康的有用性.
更多相关视频
09:26Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
Published on: January 22, 2021
7.5K
07:22Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
Published on: August 19, 2021
3.3K
相关概念视频
01:30Development of Antibiotic Resistance
1.1K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.1K
00:57Antibiotic Selection
59.3K
Overview
59.3K
01:28Biological Methods for Microbial Control
748
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
748
01:28Antimicrobial Effectiveness
870
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
870
01:23Stringent Response in E. coli
254
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
254