与线粒体功能障碍相关的代谢物甲基马龙酸与认知表现下降有关
Yige Liu1,2, Jiaxin Wang1,2, Pengyan Wu1,2
1Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
PloS one
|October 17, 2025
概括
甲基马龙酸 (MMA) 水平升高与老年人的认知能力下降有关,可能是由于线粒体功能障碍. 这突出了MMA.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 老年学是指老年学的学科.
背景情况:
- 甲基马龙酸 (MMA) 是一种与儿童神经退行相关的代谢物.
- 它在老年人慢性认知衰退中的作用尚不清楚.
- 维生素B12是MMA代谢中的关键辅酶.
研究的目的:
- 在老年人群中调查MMA水平,维生素B12和认知障碍之间的关联.
- 通过各种认知测试探索MMA和认知衰退之间的关系.
- 在认知障碍中识别与MMA代谢相关的遗传因素.
主要方法:
- 2,762名60岁以上的参与者使用认知测试 (DSST,AFT,CERAD) 进行了评估.
- 通用线性回归模型分析了MMA,维生素B12和认知表现之间的关联.
- 在与MMA相关的途径中,RNA表达特征识别了差异表达基因 (DEGs).
主要成果:
- 较高的MMA水平与DSST,AFT,CERAD-IR和CERAD-DR的认知表现下降有显著的相关性.
- 高血清维生素B12与受损的CERAD-IR得分有关.
- 在男性,老年人和那些维生素B12含量高的人群中观察到更强烈的MMA-认知衰退关联.
结论:
- 较高的MMA水平与老年人的认知能力下降有关.
- 线粒体功能障碍可能是将MMA与认知障碍联系起来的关键机制.
- 在临床上,MMA对于了解老年人慢性认知衰退具有重要意义.
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