微塑料暴露和过敏性鼻炎:网络毒理学,以及分子对接洞察力
Yaojun Wang1,2,3, Dandan Xu1,2,3
1Affiliated Hospital, Clinical Medical College, Hebei University, Baoding, Hebei, China.
PloS one
|October 17, 2025
概括
微塑料 (MP) 通过损害呼吸道组织,导致过敏性鼻炎 (AR). 关键基因DNAJB9,SQSTM1和MAPK9都与此有关,而白醇显示出潜在的治疗益处.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
背景情况:
- 微塑料 (MP) 是普遍存在的污染物,与健康问题有关.
- 在过敏性鼻炎 (AR) 病原发生过程中,MPs的具体作用尚不清楚.
研究的目的:
- 调查MPs为AR贡献的分子机制.
- 为了确定关键的分子标和潜在的治疗干预MP诱导的AR.
主要方法:
- 使用ADMETlab 3.0.0.进行常见MP (PE,PP,PVC,PS) 的in silico毒性评估.
- 从数据库中整合MP毒性目标和AR相关基因 (CTD,GSE43523).
- 生物信息分析包括功能丰富 (GO/KEGG),PPI网络,LASSO回归和分子对接 (Autodock Vina).
主要成果:
- 国会议员表现出显著的呼吸道和眼部毒性.
- 在MP毒性和AR之间确定了15个重叠的致病点.
- DNAJB9,SQSTM1和MAPK9被确定为核心调解剂,在AR患者中显著下调,并作为有效的诊断生物标志物 (AUC 0.82-0.93).
- Resveratrol证明了对这些核心标的高亲和度结合,这表明它具有治疗潜力.
结论:
- 国会议员通过涉及亡和炎症的呼吸道毒性途径加剧AR.
- DNAJB9,SQSTM1和MAPK9是MP诱导的AR中的关键调解者.
- 复星是一种有希望的治疗候选物,可以通过向编程细胞死亡途径来缓解MP诱导的AR.
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