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Updated: Jun 14, 2026

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model
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Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model

Published on: July 2, 2016

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在小鼠模型中,通过向生殖线的mRNA-LNP免疫原体,同时对HIV广泛中和的抗体前体进行多种表位

Zhenfei Xie1, Xuesong Wang1, Yu Yan1

  • 1Batista Lab, Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.

Science immunology
|October 17, 2025
PubMed
概括

同时提供针对多个HIV表位体的mRNA疫苗,有效地对抗原体前体进行广泛中和. 这种方法对艾滋病毒疫苗开发有希望,因为它克服了免疫原体之间的潜在竞争.

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Inhibitors of Virion Maturation and Assembly01:19

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As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...