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Updated: Jan 14, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

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外染色体圆形DNA促进炎症和肝细胞癌的发展

Lap Kwan Chan1,2, Juanjuan Shan1,2,3, Elias Rodriguez-Fos4

  • 1Department of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, Switzerland.

Science advances
|October 17, 2025
PubMed
概括

肝细胞中的微核释放出染色体外圆形DNA (eccDNA),触发免疫反应,驱动肝癌. 在慢性肝病模型中,阻断cGAS-STING通路会减少瘤的发展.

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