通过整合具有聚合诱导排放效应的双对接光源来提高共价有机框架的亮度
Liang Zhang1, Weihang Geng2, Xinwen Ou3
1State Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, China.
Journal of the American Chemical Society
|October 17, 2025
概括
设计高排放的共价有机框架 (COF) 是一个挑战. 这项研究引入了双接的AIEgens来增强COF光,使深层组织的体内成像成为可能.
科学领域:
- 材料科学
- 有机化学
- 纳米技术
背景情况:
- 由于分子运动和电荷转移,共价有机框架 (COF) 经常表现出弱光.
- 设计具有高光发光量子产量的COF仍然是材料科学中的一个重大挑战.
研究的目的:
- 通过整合双对接聚合诱导排放 (AIE) 基因来开发高排放的COF.
- 研究这些新型COF中光增强背后的机制.
- 在先进的生物成像中展示这些发射COF的应用.
主要方法:
- 合成新型COF,其中包括双接AIEgens.
- 光物理特征,包括光光谱和量子产量测量.
- 对光火抑制的结晶性评估和机制研究.
- 在体内对小鼠大脑血管进行三光光成像.
主要成果:
- 双接AIEgens的整合有效地抑制了非辐射衰变途径.
- 观察到增强的光生成和改善的COF结晶性.
- 一种基于甲的COF (COF-DPQP-BT) 获得了36.5%的光发量.
- 在1.2毫米的成像深度成功的三光子光成像小鼠大脑血管.
结论:
- 双接的AIEgen集成是创建高排放COF的可行策略.
- 这些放射性COF显示出深层组织生物成像应用的巨大潜力.
- 这些发现为先进的发光COF材料的合理设计提供了宝贵的见解.
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