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相关概念视频

Changes in the Appendicular Skeleton with Age01:09

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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儿科萨科佩尼亚:我们知道什么?

Marília Marques1, Fátima Baptista2

  • 1Hospital Lusíadas Lisboa. Lisboa. & Departamento de Desporto e Saúde. Centro Interdisciplinar de Performance Humana (CIPER). Faculdade de Motricidade Humana. Universidade de Lisboa. Lisboa. Portugal.

Acta medica portuguesa
|October 17, 2025
PubMed
概括
此摘要是机器生成的。

儿科肉类,儿童肌肉损失,影响生长,增加代谢和心血管疾病的风险. 通过改变生活方式和新疗法进行早期检测和干预,对于改善儿童健康结果至关重要.

关键词:
孩子孩子孩子孩子孩子孩子萨尔科佩尼亚/诊断情况萨尔科佩尼亚/病因学麻症/预防和控制

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科学领域:

  • 儿科健康 儿科健康
  • 肌肉生理学 肌肉生理学
  • 发育儿科 发育儿科

背景情况:

  • 起初与衰老相关的儿科肉症在儿童和青少年中越来越多地被发现,特别是那些患有慢性疾病的儿童和青少年.
  • 这种情况会对生长,神经发育产生负面影响,并增加长期代谢和心血管疾病的风险.
  • 导致因素包括产前营养不良,出生体重低,遗传,蛋白质摄入不足,久坐不动的生活方式,肥胖和慢性疾病.

研究的目的:

  • 审查当前对儿科sarcopenia的理解,包括其原因,后果,诊断挑战和新兴的治疗策略.
  • 突出早期检测和干预对于改善儿科健康结果的重要性.

主要方法:

  • 对儿科萨科佩尼亚现有文献的综述,包括病因因素,临床表现,诊断局限性和治疗进展.
  • 分析当前的评估工具及其在儿科患者群体中的缺陷.
  • 探索新的治疗途径,包括向药物输送,再生医学和药理干预.

主要成果:

  • 儿童肌肉质量减少导致骨健康受损,生长延迟,体力表现下降,影响生活质量.
  • 肉症复杂化慢性病儿童的临床结果,延长住院时间和增加并发症率.
  • 目前的诊断方法缺乏标准化的儿科参考值,阻碍了早期检测.

结论:

  • 儿科萨科佩尼亚带来显著的短期和长期健康风险,需要专注的注意.
  • 预防措施包括促进身体活动,均衡营养和健康的生活习惯.
  • 虽然创新的治疗方法正在出现,但儿科专用治疗指南仍未确定,强调需要进一步研究和早期干预.