根据年龄和中年更年期的更年期阶段测试和前雄激素:横截面研究的发现
Yuanyuan Wang1, Rakibul M Islam1, Molly Bond1
1Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, 3004, Australia.
EBioMedicine
|October 17, 2025
概括
水平随着年龄的增长而下降,在58-59岁左右达到最低点,独立于自然更年期. 这些发现表明更年期本身并不是进行丸激素治疗的原因.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 老年学是一门学科.
背景情况:
- 更年期与荷尔蒙变化有关,但对,氨和脱水氨 (DHEA) 的影响尚未完全理解.
- 了解这些荷尔蒙变化对于中年妇女的健康至关重要.
研究的目的:
- 为了研究40-69岁女性丸激素,安德二和DHEA度的变化.
- 为了确定自然更年期是否影响这些性类固醇水平.
主要方法:
- 澳大利亚妇女中年研究涉及8096名年龄在40-69岁之间的女性.
- 使用液体染色学-并联质谱法测量了性类固醇水平.
- 更年期状态使用生殖衰老工作坊 (STRAW) 的阶段+10个标准进行了分类.
主要成果:
- 丸激素度从40-44岁下降到55-59岁,在58-59岁左右达到最低点,随后略有增加.
- 安德二和DHEA水平从40-44岁持续下降到65-69岁.
- 根据更年期的阶段,和DHEA水平没有变化,而更年期前妇女的androstenedione水平较高.
结论:
- 水平随着年龄的增长而下降,最高点在58-59岁左右,并且不会受到自然更年期的显著影响.
- 这项研究不支持将更年期作为丸激素补充剂的唯一指示.
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