衰老会损害雄性大鼠的尿道功能:增加出口抵抗和氧化应激
Eduardo Costa Alexandre1, Alline Araujo Curiel2, Jessica Mariana Dias2
1Department of Pharmacology, Faculty of Medical Sciences, University of Campinas, Campinas, 13083-970, São Paulo, Brazil.
Autonomic neuroscience : basic & clinical
|October 17, 2025
概括
衰老的雄性大鼠表现出尿道功能障碍,包括过度收缩和放松障碍,导致下泌尿道症状 (LUTS). 这些变化与氧化应激和改变的信号通路有关,而不是组织重塑.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 衰老研究研究 衰老研究
- 身体生理学 身体生理学
背景情况:
- 年龄是男性下尿路症状 (LUTS) 的主要危险因素.
- 研究历来专注于膀和前列腺,忽视了尿道.
- 衰老引起的尿道变化尚未得到充分研究,但可能会影响排尿功能.
研究的目的:
- 调查老鼠尿道中与年龄相关的结构和功能变化.
- 为了确定这些变化对排空功能的影响.
- 探索尿道衰老背后的分子机制.
主要方法:
- 年轻的 (3.5个月) 和中年 (10个月) 的雄性Wistar大鼠的比较.
- 在体内进行囊泡测量以评估空气动力学.
- 使用电刺激和药理学剂对隔离尿道进行体外研究.
- 组织学分析和分子分析 (mRNA表达,氧化应激标志物).
主要成果:
- 中年老鼠表现出不规则的排尿,基础压力增加和膀容量改变,这表明出口阻力升高.
- 尿道收缩在响应电刺激和烯酸时增强,α1A-腺核受体mRNA增加.
- 观察到对氧化 (NO) 捐赠者的放松受损,与降低的NO水平,升高的化酶5型 (PDE5) mRNA和增加的氧化应激标志物 (超氧化物,降低的SOD,GPX,CAT) 相关.
- 没有发现显著的组织学差异或缺血症的迹象.
结论:
- 在老鼠中,衰老导致尿道超收缩性和放松障碍,导致LUTS.
- 这些功能缺陷与氧化应激和改变的上腺和NO/cGMP信号通路有关.
- 尿道老化通过分子和功能变化而不是显著的组织重塑或缺血影响尿道功能.
相关概念视频
01:20Disorders of the Male Reproductive System
4.0K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
4.0K
01:16Urethra
3.8K
The urethra is a hollowed tubular organ through which urine is expelled from the body. This structure extends from the bladder to the external opening, allowing urine to be released.
The anatomy of the urethra differs between males and females. In females, the urethra is short, measuring about 3–4 cm in length, and opens anterior to the vaginal opening. In males, the urethra is longer and passes through the penis, serving dual purposes: expelling urine and ejaculating semen. The male...
The anatomy of the urethra differs between males and females. In females, the urethra is short, measuring about 3–4 cm in length, and opens anterior to the vaginal opening. In males, the urethra is longer and passes through the penis, serving dual purposes: expelling urine and ejaculating semen. The male...
3.8K