低皮层厚度和加速大脑衰老在参与高风险饮酒的人群中
Marco Hermesdorf1, Jürgen Wellmann1, Matthias Nauck2
1Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Addictive behaviors
|October 17, 2025
概括
有风险的酒精使用与较差的大脑健康有关,包括皮质变薄和大脑加快老化超过一年. 这突显了定期饮酒对大脑的有害影响.
科学领域:
- 神经成像是一种神经成像.
- 酒精使用 研究 研究 研究
- 公共卫生 公共卫生
背景情况:
- 全球酒精消费趋势需要了解其对健康的影响.
- 以前关于酒精和大脑健康的研究在验证摄入量和范围方面存在局限性.
- 风险酒精使用被定义为每周2次或以上的2个单位酒精.
研究的目的:
- 在一般人群中调查风险酒精使用和神经成像衍生的大脑健康现象之间的关联.
- 用生物化学标记器验证自我报告的酒精摄入量.
- 评估皮质厚度,灰质体积和大脑年龄差距与酒精消费模式的关系.
主要方法:
- 使用T1权重磁共振成像 (MRI) 来获取神经成像数据.
- 在风险饮酒者 (n=123) 和非风险饮酒者 (n=403) 之间比较大脑指标 (皮层厚度,灰质体积,大脑年龄差距).
- 通过在不同组中比较马-氨基转移酶 (GGT) 水平来验证酒精摄入量.
主要成果:
- 风险酒精使用与高GGT水平相关,证实了更高的摄入量.
- 在所有四个大脑叶都观察到区域皮层厚度的显著减少.
- 患有高风险饮酒的个体的平均大脑年龄差距为1.21年,这表明大脑衰老加速.
结论:
- 风险饮酒与大脑健康状况下降有关,皮质稀薄是证据.
- 加速的大脑衰老是一般人群中高风险饮酒的显著后果.
- 这些发现强调了定期饮酒的神经毒性潜力,与当前的全球趋势相关.
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