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静脉内流诺乙化物0.19毫克Iluvien植入物用于辐射巨病
Paul T Finger1, Shayri Pillai2, Ankit Singh Tomar3
1The Department of Ocular Tumor, Orbital Disease, and Ophthalmic Radiation Therapy, The New York Eye Cancer Center, New York, NY, USA; The Department of Ophthalmology, Tulane University of Health Sciences, New Orleans, LA, USA..
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
|October 17, 2025
概括
氨醇乙胺 (FAc) 植入物有效地治疗了抗VEGF治疗不耐药的患者的放射性黄斑病 (RM). 这种治疗改善了视力,减少了黄斑,为复杂的RM病例提供了可行的选择.
科学领域:
- 眼科医生 眼科 眼科
- 辐射瘤学 辐射瘤学
- 医疗视网膜 医学视网膜
背景情况:
- 放射性黄斑病 (RM) 是一种视力危害的并发症,在膜黑色素瘤的放射治疗后出现.
- 内抗血管内皮生长因子 (抗VEGF) 药物是常见的RM的第一线治疗方法.
- 一些患者对抗VEGF治疗具有耐药性或不耐受性,需要替代治疗选择.
研究的目的:
- 为了评估长期作用的氨酸酸0.19毫克Iluvien 内 (FAc) 植入物治疗辐射巨病 (RM) 的疗效.
- 在RM患者中FAc植入后评估视力敏度,黄斑厚度和眼内压力的变化.
主要方法:
- 一个回顾性病例系列七名患者带有阴道黑色素瘤诱导的RM,他们接受了帕拉-103斑块胸膜疗法.
- 患者最初接受了抗VEGF治疗,如果耐火或不耐受,则转换为FAc植入物.
- 测量结果包括最佳校正的视敏度 (BCVA),眼内压力 (IOP) 和通过光学连贯断层扫描的中央骨厚度 (CFT).
主要成果:
- 在FAc植入后,BCVA的中位数从20/63提高到20/50.
- 中央骨厚度 (CFT) 的中位数在6个月后显著下降,并在最后一次随访时保持下降.
- 一名患者需要IOP降压治疗;三名患者停止了抗VEGF治疗. 两名患者需要重复FAc植入物.
结论:
- 长期作用的氨酸 (FAc) 植入物对抗VEGF治疗不耐药或不耐受的患者的放射性黄斑病 (RM) 有效.
- FAc植入物可以稳定斑点并改善视力敏度.
- 这种治疗可以减少对RM患者频繁注射抗VEGF的需要.
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