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在叶中静态和动态功能连接密度的交替,有或没有海马硬化

Chengru Song¹, Xiaonan Zhang¹, Keran Ma¹

¹Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Brain research bulletin

|October 17, 2025

概括

带有或没有海马硬化 (HS) 的叶 (TLE) 显示出静态功能连接密度 (FCD) 降低. 动态FCD (dFCD) 在TLE的变化可能与认知和帮助诊断相关.

科学领域:

神经科学是一个神经科学.
的研究研究.
功能神经成像功能神经成像

背景情况:

叶 (TLE) 是一种常见的焦点.
海马硬化 (HS) 是TLE中常见的病理.
了解TLE中的大脑连接对于诊断和治疗至关重要.

研究的目的:

将TLE中的静态和动态功能连接密度 (FCD) 与HS和MRI负TLE进行比较.
调查FCD与TLE认知功能之间的关系.

主要方法:

休息状态fMRI和3DT1WIMRI扫描从健康对照 (HC),TLE-HS和MRI阴性TLE患者中获得.
静态和动态的FCD是使用滑窗方法计算的.
进行了基于种子的FC分析,ROC曲线分析和斯皮尔曼相关性.

主要成果:

两组TLE都在皮新皮层中表现出减少的静态FCD.
TLE-HS显示出较大的异常FC减少在ipsilateral额叶和叶.
斜侧神经皮质的动态FCD升高是MRI阴性TLE的特征,与认知得分相关.

结论:

静态和动态FCD提供了对TLE中大脑功能障碍的互补洞察力.
在TLE-HS和MRI阴性TLE中存在FCD异常,在TLE-HS中参与度更大.
动态FCD可以为MRI阴性TLE和诊断歧视提供细微的信息.

关键词:

认知认知是一种认知.动态动态动态动态功能连接密度 (FCD) 是指功能连接密度.休息状态功能性磁共振成像 (rs-fMRI) 进行.时间叶发作时间叶.

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