白质微观结构和结构网络拓的变化与大抑郁症患者的皮质醇水平有关
Chun Yang1, Shiyun Tian1, Meichen Liu2
1Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
Brain research bulletin
|October 17, 2025
概括
患有高皮质醇水平的大型抑郁症 (MDD) 患者表现出白质 (WM) 微观结构损伤和大脑网络拓的改变. 这些变化与皮质醇水平相关,并影响神经心理功能,暗示了诊断和治疗方面的影响.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 脑下垂体上腺 (HPA) 轴失调和神经炎症与严重抑郁症 (MDD) 有关.
- 在MDD中,皮质醇 (CORT),神经炎症和白质 (WM) 微观结构损伤之间的相互作用仍然不太清楚.
研究的目的:
- 研究MDD患者皮质醇水平,白质微观结构和结构性脑网络拓学的关系.
- 探索这些因素如何与临床症状和神经心理学表现相关.
主要方法:
- 招募了59名MDD患者 (按高CORT和正常CORT水平分类) 和29名健康对照 (HC).
- 利用基于路径的空间统计 (TBSS) 用于WM微结构分析和结构网络分析.
- 应用了部分相关性,线性回归和调解分析,以检查成像发现与临床数据之间的关系.
主要成果:
- 在各组中观察到轴扩散率 (AD) 的显著差异.
- 高CORT MDD患者在平均扩散度 (MD) 和辐射扩散度 (RD) 权重网络中显示全球网络效率降低 (较低的聚类系数).
- 节点网络分析显示,高CORT MDD患者与正常CORT MDD患者和HCs患者相比,高CORT MDD患者的特定大脑区域的节点聚类系数和中间中心性发生变化.
- 轴扩散度 (AD) 和网络测量与皮质醇水平和神经心理性能相关,AD调解皮质醇和抑郁症状严重程度之间的关系.
结论:
- 患有MDD的患者,尤其是皮质醇水平高的患者,表现出明显的白质微观结构变化和结构网络拓差异.
- 这些神经生物学变化与皮质醇水平和临床结果有关,为诊断和治疗目标提供了潜在的生物标志物.
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