药物和饮食治疗发育性口吃:一个系统的审查
Sarah E Horton1, Elana J Forbes2, Ingrid E Scheffer3
1Speech and Language Group, Murdoch Children's Research Institute, Melbourne, Australia; Department of Audiology and Speech Pathology, The University of Melbourne, Melbourne, Australia.
Neuroscience and biobehavioral reviews
|October 17, 2025
概括
较新的抗精神病药物和阿托莫克赛丁在发育性口吃治疗方面表现有前途. 然而,由于当前研究的方法限制,需要进行更严格的研究来确认它们的有效性和安全性.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 语音语言病理学 语言病理学
背景情况:
- 药理学和饮食干预措施正在探索发育性口吃.
- 关于它们的有效性,可接受性,耐受性和安全性的证据有限.
- 本系统审查评估了这些治疗方法的当前证据.
研究的目的:
- 系统地审查药理和饮食治疗发育性口吃的证据.
- 评估这些干预措施的有效性,可接受性,耐受性和安全性.
- 识别研究中的差距,并为未来的研究设计提供信息.
主要方法:
- 在2024年6月之前进行全面的数据库搜索 (CENTRAL,MEDLINE,Embase,Cochrane).
- 包括关于药物或饮食治疗发育性口吃的研究,无论设计如何.
- 使用Cochrane RoB 2和ROBINS-I工具对偏差风险的评估.
主要成果:
- 39项研究分析了17种药物类别和4种饮食治疗方法,主要针对青少年/成年人.
- 较新的抗精神病药物显示出潜在的益处和比较老的抗精神病药物更好的耐受性.
- 阿托莫克赛丁与语音疗法结合使用显示改善了儿童的口吃减少;饮食治疗缺乏足够的证据.
结论:
- 对于较新的抗精神病药物和阿托莫克赛丁,有前途的发现,但方法上的局限性阻碍了最终的建议.
- 缺乏安慰剂对照试验,不一致的结果措施和小样本大小是关键问题.
- 未来的研究应该优先考虑更大规模的标准化试验,以确定疗效和安全性,并考虑个体反应.
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