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来自M1-巨细胞的外体通过MMP8-TGF-β通路促进肠道神经元损伤

Yuqiong Chen1, Kai Song2, Yi Zheng2

  • 1Provincial Key Laboratory of Research in Structure Birth Defect Disease and Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623 Guangdong, China; Department of Pediatrics, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510623 Guangdong, China.

Journal of advanced research
|October 17, 2025
PubMed
概括

携带MMP8的M1巨外体激活TGF-β信号,导致肠神经元损伤和胃肠运动障碍. 抑制MMP8为这些疾病提供了潜在的治疗策略.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.肠部神经元损伤的发生.外基因组是外基因组的组成部分.在MMP8中,MMP8是MMP8.巨细胞是一个巨细胞.

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