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Updated: Jan 14, 2026

How to Stabilize Protein: Stability Screens for Thermal Shift Assays and Nano Differential Scanning Fluorimetry in the Virus-X Project
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How to Stabilize Protein: Stability Screens for Thermal Shift Assays and Nano Differential Scanning Fluorimetry in the Virus-X Project

Published on: February 11, 2019

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使用Protposer进行蛋白质热稳定:将高度稳定的阿波弗拉夫毒素的稳定性极限和折叠可逆性推高

Antonio Hidalgo-Toledo1, Darío Bazco1, Víctor Correa-Pérez1

  • 1Biocomputation and Complex Systems Physics Institute (BIFI)-Joint Unit: GBsC-CSIC, University of Zaragoza, 50018 Zaragoza, Spain; Departamento de Bioquímica y Biología Molecular y Celular, Faculty of Science, University of Zaragoza, 50009 Zaragoza, Spain.

International journal of biological macromolecules
|October 17, 2025
PubMed
概括

蛋白质工程可以进一步稳定蛋白质. 通过使用计算工具Protposer,科学家们提高了阿波黄素的稳定性,实现了更高的化温度,并保持了新突变的催化活性.

关键词:
在阿波弗拉夫毒素.计算式的蛋白质设计蛋白质的稳定性 蛋白质的稳定性蛋白质稳定 蛋白质稳定蛋白质的热稳定 蛋白质的热稳定稳定突变的发生.

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