控制CO2对在呼吸补偿点以上的运动强度下对外围超性化学敏感性的影响
Aaron J Thompson1,2, J A Armando Riojas2,3, Paolo B Dominelli2,3
1Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
概括
周围超性化学敏感性 (PHC) 随着运动强度的增加而增加,但在呼吸补偿点 (RCP) 以上不会进一步增加. 在高强度运动期间保持异肌,与自然的二氧化碳下降 (poikilocapnia) 相比,增强PHC.
科学领域:
- 生理学 生理学 生理学
- 运动生理学 运动生理学
- 呼吸系统控制 呼吸系统控制
背景情况:
- 周围超性化学敏感性 (PHC) 是对动脉CO2变化的呼吸系统反应.
- PHC从休息增加到低强度运动,但在更高强度的高原.
- 在超呼吸补偿点 (RCP) 运动期间,动脉CO2下降可能会掩盖PHC反应.
研究的目的:
- 为了研究在超RCP炼期间异肌病对PHC的影响与poikilocapnia.
- 为了确定是否超RCP运动进一步增加PHC超出低强度运动.
- 为了检查结束潮的CO2 ([公式:见文本]) 和运动期间的PHC之间的关系.
主要方法:
- 20名健康受试者接受了最大限度的运动测试.
- 在静止状态下测量PHC,40%Wmax,在异形和异形条件下测量超RCP强度.
- 通过过渡性超膜方法 (10% CO2) 评估PHC.
主要成果:
- 与poikilocapnia相比,在超RCP运动中,PHC与isocapnia相比显著更高.
- 与40%Wmax相比,无论是异卡皮运动还是聚卡皮运动都没有显著增加PHC.
- 在poikilocapnic运动期间发现PHC和[公式:参见文本]之间存在显著的正相关性.
结论:
- 超RCP运动的代谢条件本身并不会增加PHC.
- 在高强度运动中维持异皮会增强PHC反应.
- PHC受到前刺激水平的影响,独立于运动敏感度.
相关概念视频
Chemical Factors Affecting Respiration Centers
2.1K
Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
CO2 has a potent influence on respiration and is strictly regulated....
CO2 has a potent influence on respiration and is strictly regulated....
2.1K
Respiratory Regulation of Acid-Base Balance
1.6K
Respiratory compensation is a vital physiological process that stabilizes blood plasma pH by regulating the partial pressure of carbon dioxide (PCO2), a key determinant of pH levels. Most carbon dioxide in the blood dissolves and converts into carbonic acid (H2CO3). It dissociates into hydrogen ions (H+) and bicarbonate ions (HCO3⁻). There is also an inverse relationship between PCO2 and pH.
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
1.6K
Physiological Control of Respiration
5.8K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
5.8K
Hyperpnea and Hyperventilation
2.4K
Hyperventilation refers to a higher-than-normal rate and depth of breathing, often associated with anxiety attacks. This excessive breathing surpasses the body's need to expel CO2, leading to a condition known as hypocapnia - an unusually low level of carbon dioxide in the blood. Hypocapnia can constrict cerebral blood vessels, reducing blood flow to the brain, which may result in dizziness or fainting. Early signs include tingling and muscle spasms in the hands and face, caused by falling...
2.4K
Acute Respiratory Failure-III
768
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
768
Physiology of Respiration II: Neurogenic Control of Respiration
1.8K
The neurogenic control of respiration coordinates various neural networks and pathways to regulate breathing rate and depth, meeting the body's oxygen and carbon dioxide exchange requirements. This system adapts to physiological and environmental conditions, ensuring optimal breathing patterns.
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
1.8K


