Jove
Visualize
联系我们

相关概念视频

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.4K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.

Molecular metabolism·2025
Same author

Bronchoscopic detection of aspiration in patients with bronchiectasis and Mycobacterium avium complex pulmonary infection.

Respiratory medicine and research·2025
Same author

IDO2 Drives Autoantibody Production and Joint Inflammation in a Preclinical Model of Arthritis by Repressing Runx1 Function in B Cells.

Journal of immunology (Baltimore, Md. : 1950)·2024
Same author

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.

bioRxiv : the preprint server for biology·2024
Same author

Impact of IDO1 and IDO2 on the B Cell Immune Response.

Frontiers in immunology·2022
Same author

Microbiota-mediated skewing of tryptophan catabolism modulates CD4<sup>+</sup> T cells in lupus-prone mice.

iScience·2022
Same journal

Quantification of cell viability by automated analysis of live cell imaging.

Methods in cell biology·2026
Same journal

Flow cytometry evaluation of cytotoxicity exerted by effector immune cells against tumor cells.

Methods in cell biology·2026
Same journal

Time-lapse confocal laser scanning microscopy analysis of FOOD formation.

Methods in cell biology·2026
Same journal

Screening and identification of protein-protein interaction using proximity labeling.

Methods in cell biology·2026
Same journal

Quantitative high-content profiling of mitochondrial morphology with automated statistical analysis and integrated data visualization.

Methods in cell biology·2026
Same journal

Super-resolution imaging of cell death in Drosophila tissues via expansion and pan-expansion microscopy.

Methods in cell biology·2026
查看所有相关文章
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jan 14, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.0K

自身免疫性关节炎:转基因小鼠模型和方法

Lauren M F Merlo1, Weidan Peng1, Laura Mandik-Nayak1

  • 1Lankenau Institute for Medical Research, Wynnewood, PA, United States.

Methods in cell biology
|October 17, 2025
PubMed
概括
此摘要是机器生成的。

关节炎症的临床前模型,包括K/BxN和原诱导的关节炎,对于评估自身免疫性疾病至关重要. 这些模型有助于测试免疫疗法和理解对自身免疫性疾病的遗传贡献.

关键词:
自动抗体是一种自身抗体.这是一种自身免疫力.与免疫相关的不良事件鼠标模型 鼠标模型类风湿性关节炎 类风湿性关节炎 类风湿性关节炎

更多相关视频

Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

14.1K
A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
11:03

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

Published on: October 30, 2019

8.9K

相关实验视频

Last Updated: Jan 14, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.0K
Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

14.1K
A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
11:03

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

Published on: October 30, 2019

8.9K

科学领域:

  • 免疫学 免疫学 免疫学
  • 类风湿病学 类风湿病学
  • 临床前研究 临床前研究

背景情况:

  • 自身免疫性疾病正在增加,需要在临床前模型中进行评估.
  • 免疫疗法可能会导致自身免疫性副作用,需要仔细评估.
  • 风湿性疾病是影响关节的常见自身免疫性疾病.

研究的目的:

  • 描述用于自身免疫研究的关节炎症的常见小鼠模型.
  • 突出K/BxN和原诱导关节炎模型的实用性.
  • 为评估免疫疗法和自身免疫性疾病中的遗传因素提供工具.

主要方法:

  • 自免疫性关节炎的K/BxN T细胞转基因模型的描述.
  • 在K/BxN模型中解释关节炎诱导方法 (自发,血清转移,收养转移).
  • 对原诱导关节炎模型的概述.

主要成果:

  • K/BxN模型提供了快速,同步和高度透的关节炎发展.
  • 可以通过多种方法诱导K/BxN关节炎.
  • 无论是K/BxN还是原诱导性关节炎模型都适合用于治疗测试.

结论:

  • 在基因研究中,K/BxN模型及其C57BL/6背景是有利的.
  • 这些小鼠模型对于评估单克隆抗体和纳米疗法等疗法的自身免疫副作用非常有价值.
  • 描述的模型可以帮助阐明对自身免疫性疾病的遗传贡献.