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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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相关实验视频

Updated: Jan 14, 2026

Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples
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Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples

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使用成像质细胞计数据分析瘤微环境的分析.

Zuzana Loncova1, Zlatko Trajanoski1, Dietmar Rieder1

  • 1Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.

Methods in cell biology
|October 17, 2025
PubMed
概括

像成像质细胞计 (IMC) 这样的先进成像技术揭示了瘤微环境 (TME) 的复杂性. 对IMC数据的分析工具改善了对细胞相互作用的理解,以便更好地治疗癌症.

科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 生物技术是生物技术.
  • 计算生物学 计算生物学

背景情况:

  • 瘤微环境 (TME) 对瘤进展,免疫反应和治疗疗效至关重要.
  • 了解TME异质性和细胞与细胞相互作用是破译瘤动态的关键.
  • 高维成像技术为研究复杂的TME提供了新的途径.

研究的目的:

  • 介绍分析方法和用于成像质细胞计 (IMC) 数据的工具.
  • 解开TME内部的细胞组成,空间组织和相互作用.
  • 增强对癌症,免疫和树皮细胞之间的相互作用的理解.

主要方法:

  • 使用多重免疫光成像,成像质细胞计 (IMC) 和多重离子束成像 (MIBI).
  • 开发和应用IMC数据的分析工具.
  • 实现了高分辨率的40多种蛋白质在现场的同时分析.

主要成果:

  • 证明了IMC提供有关TME组成和细胞空间组织的详细见解的能力.
  • 促进了高分辨率的细胞相互作用的现场分析,最小的交叉通话.
  • 提供了对TME内部复杂细胞格局的更深入的理解.
关键词:
细胞对细胞的相互作用.高维成像 - - 高维成像图像化 CyTOF 的成像图像质量细胞计 (IMC) 的使用空间分析是一种空间分析.瘤微环境 (TME) 是指瘤的微环境.瘤免疫背景结构

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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
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相关实验视频

Last Updated: Jan 14, 2026

Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples
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Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples

Published on: June 29, 2022

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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

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Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
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结论:

  • IMC是剖析TME复杂性和细胞相互作用的强大工具.
  • 开发的分析方法提高了IMC数据对生物发现的有用性.
  • 对TME的更好理解有助于开发新的治疗策略.