与免疫检查点抑制剂相关的口腔面部不良事件:使用大型现实世界数据集
Stella O Oyewole1, Adepitan A Owosho2
1College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Oral surgery, oral medicine, oral pathology and oral radiology
|October 17, 2025
概括
免疫检查点抑制剂 (ICI) 即使单独使用时也可能导致显著的面部或口腔副作用. 监测口腔并发症,如消化不良和面部麻木,对于患者护理至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 口腔医学是指口腔医学.
背景情况:
- 免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗,单独或与其他疗法一起使用.
- 了解ICI产生的口服不良事件,特别是单疗法,至关重要.
研究的目的:
- 在接受ICI单一治疗的患者中调查口腔面部不良事件.
- 为了确定与ICI使用相关的口腔并发症的患病率和类型.
主要方法:
- 对TrinetX真实世界医疗保健数据集的回顾性分析.
- 包括仅用ICI治疗的患者,不包括接受化疗或放射治疗的患者.
- 将口腔面部不良事件分为异口,口腔粘膜疾病和口腔面部神经疾病的分类.
主要成果:
- 在接受ICI单疗的15638名患者中,10%的患者发生了与面部或面部免疫相关的不良事件 (irAEs).
- 口腔面部神经病变 (56.97%) 是最常见的,其次是口腔粘膜疾病 (33.95%) 和异口腔 (9.07%).
- 缺食症 (3.6%) 和面部麻木/三神经疼痛 (1.63%) 是最常见的irrAEs.
结论:
- 即使是单独治疗,ICI也可能导致显著的口腔面部并发症.
- 提高口服副作用的意识和早期检测对于管理ICI治疗至关重要.
- 迅速管理口腔并发症可以改善患者的生活质量.
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