欧盟红色狼学会 (EULAR) 关于治疗带有脏病的全身性红色狼的建议:2025年更新
Antonis Fanouriakis1, Myrto Kostopoulou2, Hans-Joachim Anders3
1Rheumatology and Clinical Immunology Unit, "Attikon" University Hospital, National Kapodistrian University of Athens, Greece.
Annals of the rheumatic diseases
|October 17, 2025
概括
更新的指导方针提供专家对管理狼性炎 (系统性红斑狼与脏参与) 的共识. 这些建议包含了改善患者护理和治疗策略的新证据.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 系统性红斑狼 (SLE) 经常涉及脏,这种情况被称为狼性炎.
- 现有的管理指南需要更新,以反映治疗和理解的最新进展.
研究的目的:
- 更新2019年欧洲风湿病学协会联盟 (EULAR) /欧洲脏协会/欧洲透析移植协会 (ERA-EDTA) 关于狼性炎管理的建议.
- 将新出现的证据和最近的发展纳入临床实践指南中.
主要方法:
- 组建了一个由专家组成的国际工作组,遵守EULAR标准操作程序.
- 系统的文献研究 (2019年1月至2024年3月) 和修改后的Delphi方法被用于制定问题并达成专家共识.
- 新证据与之前的更新一起被严格审查.
主要成果:
- 制定了四项总体原则和13项建议,重点关注诊断,治疗目标和治疗里程碑.
- 该指南涵盖免疫调节疗法 (抗疟疾药物,葡萄皮质类药物,免疫抑制剂,生物药物),非免疫支持性护理,计划生育和功能衰竭管理.
- 提供了关于组合治疗,糖皮质激素逐渐减少,治疗持续时间和耐火性疾病管理的具体建议.
结论:
- 更新的EULAR建议提供了基于证据和专家的共识,用于管理狼性炎.
- 准则是根据疾病严重程度量身定制的,考虑长期疗效,安全性,成本和药物可用性.
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