在Cystic Fibrosis (SCREEN-CF) 中瘤的coloREctal评估中进行便和症状检测
Nicole A Taylor1, Sheila Sivam2, Josie van Dorst3
1Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW, 2050, Australia; University of New South Wales, School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine and Health, Randwick Clinical Campus, Sydney, NSW, 2052, Australia.
概括
在患有囊性纤维化 (pwCF) 的人群中,结肠直肠癌查是非常重要的,因为瘤发生率很高. 便calprotectin (FC) 在pwCF中显示出前恶性和恶性病变的非侵入性查的前景.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- 患有囊性纤维化 (pwCF) 的人患结直肠癌 (CRC) 的风险较高.
- 在pwCF中,标准结肠镜查CRC存在由于并发症和手术风险的挑战.
研究的目的:
- 评估非侵入性便测试,以检测pwCF中的结直肠瘤.
- 评估免疫化学便隐性血液测试 (iFOBT),便calprotectin (FC) 和便瘤pyruvate kinase异酶类型M2 (TuM2-PK) 的诊断性能,以检测腺瘤多和结肠直肠恶性瘤.
主要方法:
- 进行了一项前性观察性研究,pwCF符合结肠镜查指南.
- 便样本是在结肠镜检查后三个月内收集的,用于分析.
- 计算了iFOBT,FC和TuM2-PK的诊断性能指标和最佳切断值.
主要成果:
- 这项研究包括49名参与者,24.5%患有腺瘤多,4%患有胆结肠恶性瘤.
- 较高的身体质量指数 (BMI) 与异常的结肠镜检查结果有关 (p = 0.03).
- 在检测腺瘤多体 (91.7%的敏感度,95.5%的NPV在≤100μg/g) 和恶性瘤 (100%的敏感度和特异性在≥1000μg/g) 中,FC表现出高的灵敏度和特异性.
结论:
- 结肠直肠癌查对于pwCF是必不可少的,因为瘤的患病率很高.
- 像FC这样的非侵入性查方法可能有助于pwCF的风险分层.
- 对CFTR调节器治疗对选试验性能的有效性需要进一步研究.
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