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双作用细胞纳米粒子用于有效的 (Pb2+) 排毒

Wei-Ting Shen¹, Jiayuan Alex Zhang¹, Yiyan Yu¹

¹Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, Shu and K.C. Chien and Peter Farrell Collaboratory, University of California San Diego, La Jolla, California 92093, United States.

|October 17, 2025

概括

新的神经元模拟纳米粒子通过中和毒性和氧化应激有效地排毒 (Pb2+). 这种双重作用的方法对治疗中毒有望带来系统性和神经保护性益处.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
毒理学毒理学毒理学

背景情况:

暴露于 (Pb2+) 是一个重要的公共卫生问题,由于其普遍存在和严重的毒性.
现有的中毒治疗方法在有效性和向性治疗方面存在局限性.

研究的目的:

开发和评估新的双作用,神经元模拟细胞膜涂层纳米粒子 (CNPs) 进行有效的 (Pb2+) 排毒.
在中毒的体外和体外模型中评估这些纳米粒子的治疗潜力.

主要方法:

在金属有机框架 (MOF) 内封装DNA体的CNP的配方,覆盖SH-SY5Y细胞膜.
在实验室评估Pb2+的结合能力,体稳定性和中和Pb2+诱导的毒性,氧化应激和SH-SY5Y细胞中的脂质过氧化.
在中毒的小鼠模型中的治疗功效的体内评估,包括生存率,器官损伤和行为恢复,以及毒性研究.

主要成果:

开发的Neuron-MOF/aptamer-NP表现出强大的Pb2+结合,稳定性和对DNA泄漏的抗性.
试验室研究表明,Pb2+毒性,氧化应激和脂质过氧化的强烈双作用中和.
在体内研究显示,中毒小鼠的生存率提高,器官损伤减少,认知和运动功能恢复,没有观察到急性毒性.

结论:

神经元-MOF/体-NP代表了针对排毒的强大和生物相容的治疗平台.
开发的纳米粒子为治疗中毒提供了显著的系统性和神经保护性益处.
这种方法有望推进针对重金属毒性的治疗策略.

关键词:

一个aptamer的应用程序.细胞膜涂层是细胞膜的涂层.细胞纳米粒子是什么重金属的排毒重金属的排毒.中毒中毒中毒

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