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使用全长16S rRNA基因metabarcoding基因探索乳酪菌群及其对早期小牛肠道菌群发育的影响
Leire Urrutia-Angulo1, Medelin Ocejo1, Timur Yergaliyev2,3
1Animal Health Department, NEIKER - Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Bizkaia Science and Technology Park 812L, 48160, Derio, Bizkaia, Spain.
Scientific reports
|October 17, 2025
概括
牛犊肠道微生物群的发育由胆乳开始,组成从出生到57天大大改变. 早期的抗微生物治疗对正在发展的肠道微生物群产生了最小的长期影响.
科学领域:
- 兽医微生物学 兽医微生物学
- 动物健康 动物健康
- 肠道微生物组研究研究
背景情况:
- 早期的肠道微生物组对于小牛的健康和发育至关重要.
- 大奶粉在播种最初的肠道微生物群中发挥着重要作用.
- 饮食,环境和治疗等因素会影响微生物的组成.
研究的目的:
- 为了分析小牛的胆乳和生命早期的便微生物群.
- 评估抗微生物治疗对小牛肠道微生物群的影响.
- 了解从出生开始微生物殖民的动态.
主要方法:
- 使用牛津纳米孔技术对全长16S rRNA基因进行测序.
- 在第1,16和57天对乳酪和小牛便样本的分析.
- 从分类学分类到物种级别和贝塔多样性分析.
主要成果:
- 微生物的丰富性和多样性从第1天增加到第57天.
- 结肠杆菌对早期的肠道殖民有着显著的贡献.
- 抗菌药物治疗没有导致显著的长期改变微生物群的多样性或组成.
结论:
- 大奶粉是建立小牛肠道微生物群的关键来源.
- 牛犊肠道微生物群在生命早期经历了显著的发展和稳定.
- 抗微生物干预似乎对生命早期的肠道微生物群产生了有限的持久影响.
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