在冷胚胎转移后单独分娩的胚胎质量和先天性形风险
Linqing Du1,2,3,4, Tian Ye1,2,3,4, Wenqian Fan1,2,3,4
1Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, No.1, Jianshe Road, Zhengzhou, China.
Scientific reports
|October 17, 2025
概括
辅助生殖技术 (ART) 中的胚胎细胞质量不会影响先天性形风险. 这项研究表明,使用形态差的胚胎囊细胞可以改善治疗的可访问性,并减少胚胎的浪费.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 临床遗传学 临床遗传学
背景情况:
- 胚胎细胞形态质量是辅助生殖技术 (ART) 胚胎选择的关键因素.
- 囊胚质量与先天性形风险之间的关联尚未得到充分证实,这影响了临床决策.
- 当前的临床实践往往优先考虑形态上优越的囊胚,可能导致胚胎浪费.
研究的目的:
- 调查胚胎细胞形态质量与冷胚胎移植后先天性形的发生率之间的关系.
- 为了确定通过加德纳分级系统评估的胚胎细胞质量是否会影响新生儿的结果.
- 在ART中为胚胎选择提供基于证据的指导,潜在地改善治疗的可访问性.
主要方法:
- 从2014年1月到2023年6月,对3986个冷胚胎移植周期进行了回顾性队列研究.
- 使用加德纳分级系统分类的芽细胞; 1:2倾向得分匹配控制混因子.
- 分析了1743个单独的出生,比较了质量好和质量差的胚胎细胞之间的结果.
主要成果:
- 质量好 (1.72%) 和质量差 (2.07%) 的胚胎囊 (aOR 1.14,P=0.7310) 之间的先天性形风险没有显著差异.
- 两组之间在特定的ICD-10器官特异性形中没有发现显著差异.
- 包括早产,低出生体重和产科并发症在内的次要结局也显示没有显著的群体间差异.
结论:
- 胚胎细胞形态质量本身似乎不是先天性形风险的重要预测因素.
- 当高质量的选择有限时,可以考虑将形态差的芽细胞移植,这可能会增加ART成功率.
- 这些发现支持了更具包容性的胚胎选择标准,旨在减少胚胎丢弃和提高患者获得生育治疗的机会.
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