相关实验视频

Updated: Jan 14, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

一种工程 IL-21 变体是抗瘤免疫疗法的强有力的抗瘤候选者

Hui Wu¹, Ya-Ping Cheng¹, Yu-Long Liu¹

¹Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS) and Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Acta pharmacologica Sinica

|October 17, 2025

概括

一种新的IL-21变体 (IL-21V) 显示了增强的结合和信号传递,导致在临床前模型中具有强大的广谱抗瘤活性. 这种工程性细胞因子为癌症免疫治疗提供了一个有希望的新途径.

科学领域:

免疫学免疫学免疫学
生物技术是生物技术.
在瘤学瘤学.

背景情况:

介素-21 (IL-21) 是一种免疫激动剂,在癌症免疫治疗中有效性有限.
工程IL-21对于提高其治疗潜力至关重要.

研究的目的:

开发一种具有改善IL-21受体 (IL-21R) 结合和增强抗瘤活性的IL-21变体.
在临床前癌症模型中评估工程IL-21变体的疗效.

主要方法:

由IL-21/IL-21R结构指导的酵母表面显示IL-21突变库的构建.
用磁珠分类和光激活细胞分类来隔离和评估IL-21变体.
评估受体结合亲和力,STAT3信号激活,以及体内抗瘤疗效.

主要成果:

确定了一种IL-21变种 (IL-21V),具有四种突变 (Q19L,Y23N,V69T,K73Q).
与野生型IL-21相比,IL-21V的IL-21R结合亲和力增加了7倍,STAT3信号增加了50倍.
IL-21V对黑色素瘤和结直肠癌模型表现出显著的广泛抗瘤活性,优于野生型IL-21.

结论:

设计的IL-21V具有显著增强的IL-21R结合和STAT3激活.
在临床前设置中,IL-21V显示出强大且广泛的抗瘤疗效.
IL-21V代表了先进癌症免疫治疗的有希望的候选人.

关键词:

这种IL-21变种是IL-21的变种.癌症免疫疗法免疫疗法结肠直肠癌是什么意思工程化细胞因子黑色素瘤是一种黑色素瘤.

更多相关视频

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.