相关实验视频

Updated: Jan 14, 2026

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate

Published on: September 9, 2011

甲作为小分子STING激动剂发挥抗瘤免疫疗法的作用

Man Zhao^1,2, Zu-Yi Jin¹, Wei-Zhen Fan¹

¹State Key Laboratory of Anti-infective Drug Discovery and Development, Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.

Acta pharmacologica Sinica

|October 17, 2025

概括

甲 (ZPT) 激活了干扰素基因 (STING) 途径的刺激器,显示出显著的抗瘤作用. 这项研究揭示了ZPT.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
在瘤学瘤学.

背景情况:

干扰素基因刺激器 (STING) 对先天免疫和抗瘤反应至关重要.
发现STING的小分子激动剂对于癌症免疫疗法至关重要.
甲 (ZPT) 是一种抗真菌药物,它通过未知的机制表现出先前的抗瘤活性.

研究的目的:

通过激活STING通路,研究ZPT是否具有抗癌作用.
描述ZPT和STING蛋白之间的相互作用.
在体内评估ZPT的抗瘤疗效和免疫调节作用.

主要方法:

在体外结合测试以确定ZPT对STING的亲和力.
基于细胞的测试来评估ZPT的STING-TBK1-IRF3信号激活.
在体内研究中,使用接受ZPT治疗的MC38瘤携带小鼠,以评估瘤生长抑制和免疫细胞激活.

主要成果:

ZPT与STING蛋白结合,其K_D值为2.72微米.
根据剂量,ZPT会激活THP-1细胞中的STING-TBK1-IRF3信号通路.
施用ZPT可抑制小鼠的瘤生长,增强T细胞激活 (CD45+,CD3+,CD8+),并增加IL-6的分泌.

结论:

ZPT作为STING的小分子激活剂.
通过STING激活和免疫调节,ZPT显示出强大的抗瘤作用.
作为一种针对STING通路的癌症治疗新型免疫治疗剂,ZPT具有前途.

更多相关视频

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Drugs that Stabilize Microtubules

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...