阻塞性睡眠呼吸暂停和女性性功能障碍之间的关联:系统性审查和元分析
Han Qin1, Mei Yang1, Xiaojie Chen1
1Department of Special Medicine, Daping Hospital, Army Medical University, No 10, Changjiang Branch Road, Yuzhong District, Chongqing, 400042, China.
Archives of gynecology and obstetrics
|October 17, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 显著增加女性性功能障碍 (FSD) 的风险. 与对照组相比,患有OSA的女性经历了更高的FSD率和更低的性功能得分.
科学领域:
- 生殖健康 生殖健康
- 睡眠医学 睡眠医学
- 临床流行病学临床流行病学
背景情况:
- 女性性功能障碍 (FSD) 是一种普遍影响女性生活质量的疾病.
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的睡眠障碍,具有潜在的全身影响.
- 在科学文献中,OSA和FSD之间的联系仍未得到充分探索.
研究的目的:
- 系统地审查和元分析现有研究,以澄清OSA和FSD之间的关联.
- 为量化被诊断为OSA的女性FSD的风险.
- 用验证的指标评估OSA对女性性功能的影响.
主要方法:
- 在PubMed,Embase和Cochrane图书馆数据库中进行了全面的搜索,截至2024年11月.
- 包括调查OSA和FSD的临床观察研究.
- 用随机效应模型计算了FSD患病率和女性性功能指数 (FSFI) 评分的标准化平均差异的聚合概率比率.
主要成果:
- 分析包括11项研究,共有超过260万参与者 (1317856名女性患有OSA和1317899名对照).
- 患有OSA的女性表现出明显增加的FSD风险 (OR2.56;95% CI 1.38-4.75).
- 在患有OSA的女性中观察到统计学上显著较低的FSFI得分 (SMD -0.72;95% CI -1.24至 -0.20),表明性功能较差.
结论:
- 女性性功能障碍与阻塞性睡眠呼吸暂停有显著的关联.
- 与非OSA对照组相比,被诊断患有OSA的女性表现出更高的性功能障碍患病率.
- 进一步的研究是有必要的,以巩固对OSA-FSD关系的理解,并探索潜在的干预措施.
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