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在固体瘤中进行CAR-T细胞免疫疗法的体外研究的瘤芯片

Haijiao Liu^1,2, Estela Noguera-Ortega³, Xuanqi Dong¹

¹Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

Nature biotechnology

|October 17, 2025

概括

研究人员开发了一种新的瘤在芯片上的系统,用于模拟固体瘤中仿真抗原受体 (CAR) -T细胞治疗. 这种微生理系统增强了对癌症与免疫相互作用的理解,并有助于开发新的癌症治疗方法.

科学领域:

生物医学工程生物医学工程
癌症免疫学癌症免疫学
翻译性瘤学翻译性瘤学

背景情况:

对癌症-免疫相互作用的有限理解阻碍了固体瘤的仿真抗原受体 (CAR) -T细胞治疗.
开发有效的CAR-T细胞疗法需要更好的瘤微环境模型.

研究的目的:

介绍一个微工程系统,用于血管化的人类瘤,用于模拟CAR-T细胞活动.
测试一种化基因导向的CAR-T细胞工程策略,并确定固体恶性瘤的治疗点.

主要方法:

微工程瘤芯片系统的开发,使用血管化的人类瘤扩展剂.
控制免疫细胞的输液以模拟瘤微环境中的CAR-T细胞功能.
测试CAR-T细胞工程策略和在体内小鼠模型中的验证;代谢学分析.

主要成果:

证明了该系统在血管化肺腺癌中模拟,可视化和询问CAR-T细胞功能的能力.
验证了在恶性多叶膜间皮瘤中使用化学激素指导的CAR-T细胞工程策略.
确定了一种潜在的治疗标和生物标志物,用于提高肺腺癌中CAR-T细胞的疗效.

结论:

微生理系统为推进采用细胞疗法提供了一个有前途的体外技术.
这个平台可以加速CAR-T细胞治疗固体瘤和其他疾病的开发.
该研究提供了关于癌症与免疫相互作用以及潜在的治疗策略的见解.

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