剩余胆固醇炎症指数与治疗内血管血栓切除术的缺血性中风患者的临床结果之间的关系
Yan E1, Jingwen Qi1, Shuaiyu Chen1
1Department of Neurology, Nanjing First Hospital, Nanjing Medical University, 210000, No.68 Changle Road, Nanjing, Jiangsu Province, China.
概括
升高的残留胆固醇炎症指数 (RCII) 与中风患者治疗内血管血栓切除术 (EVT) 的不良结果有关. 较高的RCII水平预测大血管闭塞中风后EVT后的功能恢复较差.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 生物化学 生化学
背景情况:
- 剩余胆固醇炎症指数 (RCII) 与缺血性中风的发病因子有关.
- 了解RCII在中风治疗中的作用对于患者的治疗结果至关重要.
研究的目的:
- 调查RCII水平与大血管闭塞性中风患者的临床结果之间的关联,这些患者接受了内血管血栓切除术 (EVT) 治疗.
主要方法:
- 来自中国两家中风中心的935名患者的回顾性分析.
- 在入院后24小时内,RCII从脂质资料和hs-CRP计算.
- 糟糕的结果被定义为修改后的兰金尺度得分>2在90天;使用多变量逻辑回归分析.
主要成果:
- 总共有935名患者被纳入; 49.6%的患者在90天后经历了糟糕的结果.
- RCII与EVT后90天的不良结果显著相关 (OR每1SD增加1.358;P=0.009).
- 较高的RCII四分位数与糟糕的结果有更强的关联 (第四四分位数与第一四分位数相比 OR: 3.926; P=0.001).
结论:
- 升高的RCII水平与前部循环大血管封闭性中风患者的90天功能表现不佳显著相关.
- 研究结果表明RCII是潜在的预后生物标志物.
- 需要进一步的多中心研究来验证研究结果并制定有针对性的干预措施.
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