血清铜与成年人过度活跃的膀之间的关联:一个截面研究
Mingming Xu1, Qinghua Wang1, Youyang Zhang2
1Department of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Biological trace element research
|October 17, 2025
概括
血清铜水平升高与成年人过度活性膀 (OAB) 的风险增加有关. 这种关联在女性中尤为明显,这表明铜的潜在毒性作用.
科学领域:
- 环境健康 环境健康
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 铜是一种常见的重金属暴露,与各种疾病有关.
- 血清铜与过活性膀 (OAB) 风险之间的关系仍未得到研究.
研究的目的:
- 为了研究血清铜水平与成年人患过度活性膀 (OAB) 的风险之间的潜在关联.
主要方法:
- 一项横截面研究利用了2011-2016年国家健康和营养检查调查 (NHANES) 的4600名成年参与者的数据.
- 使用过度活性膀症状评分 (OABSS) 评估过度活性膀 (OAB).
- 用单变量和多变量加权后勤回归模型和子组分析来评估相关性.
主要成果:
- 血清铜度在OAB组 (127.50) 与非OAB组 (117.86) 相比显著更高.
- 较高的血清铜水平与OAB风险有关,即使经过对共变量进行调整 (OR=1.551,p=0.005).
- 这种关联在女性中是显著的 (OR=1.630,p=0.025).
结论:
- 过多的血清铜与过度活性膀 (OAB) 的风险增加正相关.
- 这种关联在女性中尤为显著.
- 需要进一步的前性队列和机制研究来证实铜和OAB之间的因果关系.
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